Effect of plasma free fatty acids on lung function in male COPD patients

Arslan, S., Yildiz, G., Özdemir, L., Kaysoydu, E. & Özdemir, B. Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease. Korean J. Intern. Med. 34, 108–115 (2019).
Google Scholar
Gutiérrez Villegas, C., Paz-Zulueta, M., Herrero-Montes, M., Parás-Bravo & P. Madrazo Pérez, M. Cost analysis of chronic obstructive pulmonary disease (COPD): a systematic review. Health Econ. Rev. 11, 1–12 (2021).
Google Scholar
Wattanachayakul, P., Rujirachun, P., Charoenngam, N. & Ungprasert, P. Chronic obstructive pulmonary disease is associated with a higher level of serum uric acid. A systematic review and meta-analysis. Adv. Respir Med. 88, 215–222 (2020).
Google Scholar
Varmaghani, M. et al. Prevalence of asthma, COPD, and chronic bronchitis in Iran: a systematic review and meta-analysis. Iran. J. Allergy Asthma Immunol. 15, 93–104 (2016).
Google Scholar
Hikichi, M., Mizumura, K., Maruoka, S. & Gon, Y. Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke. J. Thorac. Dis. 11, S2129–S2140 (2019).
Google Scholar
Vlahos, R. & Bozinovski, S. Glutathione peroxidase-1 as a novel therapeutic target for COPD. Redox Rep. 18, 142–149 (2013).
Google Scholar
Tse, H. N. et al. Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD. Chest 146, 611–623 (2014).
Google Scholar
Kiepura, A., Stachyra, K. & Olszanecki, R. Anti-atherosclerotic potential of free fatty acid receptor 4 (FFAR4). Biomedicines 9 (2021).
Zhang, L. et al. A high serum-free fatty acid level is associated with cancer. J. Cancer Res. Clin. Oncol. 146, 705–710 (2020).
Google Scholar
Frommer, K. W. et al. Free fatty acids: Potential proinflammatory mediators in rheumatic diseases. Ann. Rheum. Dis. 74, 303–310 (2015). https://doi.org/10.1136/annrheumdis-2013-203755
Stefanovski, D., Boston, R. C. & Punjabi, N. M. Sleep-disordered breathing and free fatty acid metabolism. Chest 158, 2155–2164 (2020).
Google Scholar
Cheshmehkani, A., Senatorov, I. S., Dhuguru, J., Ghoneim, O. & Moniri, N. H. Free-fatty acid receptor-4 (FFA4) modulates ROS generation and COX-2 expression via the C-terminal b -arrestin phosphosensor in raw 264.7 macrophages. Biochem. Pharmacol. 146, 139–150 (2017).
Google Scholar
Nader, H. & Moniri Free-fatty acid receptor-4 (GPR120): cellular and molecular function and its role in metabolic disorders. Physiol. Behav. 176, 139–148 (2017).
Google Scholar
Mizuta, K. et al. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol. 309, L970–L982 (2015).
Google Scholar
Sureda, A. et al. Effect of free fatty acids on biodiesel production. Nutrients 146, 1–13 (2019).
Wang, Y., Xu, J., Meng, Y., Adcock, I. M. & Yao, X. Role of inflammatory cells in airway remodeling in COPD. Int. J. COPD 13, 3341–3348 (2018). https://doi.org/10.2147/COPD.S176122
Dandona, P. et al. Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes 52, 2882–2887 (2007).
Google Scholar
Liguori, I. et al. Oxidative stress, aging, and diseases. Oxidative Stress Dis. 13, 757–772 (2018).
Google Scholar
Kotlyarov, S. & Kotlyarova, A. Anti-inflammatory function of fatty acids and involvement of their metabolites in the resolution of inflammation in chronic obstructive pulmonary disease. Int. J. Mol. Sci. 22, 1–31 (2021).
Google Scholar
Shiri, H. et al. Relationship between types and levels of free fatty acids, peripheral insulin resistance, and oxidative stress in T2DM: a case-control study. PLoS One. 19, e0306977 (2024).
Google Scholar
Mohammadi, A., Fallah, H. & Gholamhosseinian, A. Antihyperglycemic effect of rosa damascena is mediated by PPAR.γGene expression in animal model of insulin resistance. Iran. J. Pharm. Res. 16, 1080–1088 (2017).
Google Scholar
Mohammadi, A., Gholamhoseinian, A. & Fallah, H. Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats. Iran. J. Basic. Med. Sci. 17, 263–270 (2014).
Google Scholar
Kangani, C. O., Kelley, D. E. & DeLany, J. P. New method for GC/FID and GC–C-IRMS analysis of plasma free fatty acid concentration and isotopic enrichment. J. Chromatogr. B. 873, 95–101 (2008).
Google Scholar
Perng, D. W. & Chen, P. K. The relationship between Airway Inflammation and exacerbation in chronic obstructive pulmonary disease. Tuberc Respir Dis. 80, 325–335 (2017).
Google Scholar
Miyamoto, J. et al. Nutritional signaling via free fatty acid receptors. Int. J. Mol. Sci. 17, 450 (2016).
Google Scholar
Theodore, H., Tulchinsky, Elena, A. & Varavikova The New Public Health, Vol. 1 (Elsevier, 2015).
Acharyya, A., Shahjahan, M., Mesbah, F. B., Dey, S. K. & Ali, L. Association of metabolic syndrome with chronic obstructive.pdf. Indian Chest Soc. 33, 385–390 (2016).
Li, J. et al. Chemerin A Potential Regulator of Inflammation and .pdf. BioMed Res. Int. 2, 1–20 (2020)
Islam, E. A., Limsuwat, C., Nantsupawat, T., Berdine, G. G. & Nugent, K. M. The association between glucose levels and hospital outcomes in patients with acute exacerbations of chronic obstructive pulmonary disease. Ann. Thorac. Med. 10, 94–99 (2015).
Google Scholar
Gläser, S., Krüger, S., Merkel, M., Bramlage, P. & Herth, F. J. F. Chronic obstructive pulmonary disease and diabetes mellitus: A systematic review of the literature. Respiration 89, 253–264 (2015). https://doi.org/10.1159/000369863
Najafipour, H. & Beik, A. The impact of opium consumption on blood glucose, serum lipids and blood pressure, and related mechanisms. Front. Physiol. 7, (2016).
Markeli, I. et al. Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease. Nutr. Metabolism Cardiovasc. Dis. 31, 153–161 (2021).
Google Scholar
Young, R. P. & Hopkins, R. J. Chronic obstructive pulmonary disease (COPD) and lung cancer screening. Transl Lung Cancer Res. 7, 347–360 (2018).
Google Scholar
Chen, H. et al. Lipid metabolism in chronic obstructive pulmonary disease. Int. J. Chronic Obstr. Pulmonary Disease. 14, 1009–1018 (2019).
Google Scholar
Xuan, L. et al. Association between chronic obstructive pulmonary disease and serum lipid levels: A meta-analysis. Lipids Health Disease 17, 1–8 (2018). https://doi.org/10.1186/s12944-018-0904-4
Zafirova-Ivanovska, B. et al. The level of cholesterol in COPD patients with severe and very severe stage of the disease. Open. Access. Maced J. Med. Sci. 4, 277–282 (2016).
Google Scholar
Taniguchi, A., Tsuge, M., Miyahara, N. & Tsukahara, H. Reactive oxygen species and antioxidative defense in chronic obstructive pulmonary disease. Antioxidants 10, 1–22 (2021).
Google Scholar
Zinellu, E. et al. Oxidative stress biomarkers in chronic obstructive pulmonary disease exacerbations: a systematic review. Antioxidants 10, 1–9 (2021).
Dong, J. et al. Mitochondrial membrane protein mitofusin 2 as a potential therapeutic target for treating free fatty acid–induced hepatic inflammation in dairy cows during early lactation. J. Dairy. Sci. 103, 5561–5574 (2020).
Google Scholar
Wiegman, C. H., Li, F., Ryffel, B., Togbe, D. & Chung, K. F. Oxidative stress in ozone-Induced chronic lung inflammation and emphysema: a facet of chronic obstructive pulmonary disease. Front. Immunol. 11, (2020).
Wada, H. et al. Reduction in plasma free fatty acid in patients with chronic obstructive pulmonary disease. Am. J. Respir Crit. Care Med. 171, 1465–1465 (2005).
Google Scholar
Hsieh, M. J., Yang, T. M. & Tsai, Y. H. Nutritional supplementation in patients with chronic obstructive pulmonary disease. J. Formos. Med. Assoc. 115, 595–601 (2016).
Google Scholar
Li, X. et al. Endogenously generated omega-3 fatty acids attenuate vascular inflammation and neointimal hyperplasia by interaction with free fatty acid receptor 4 in mice. J. Am. Heart Assoc. 4, 1–16 (2015).
Google Scholar
Kemper, T. A. et al. Higher plasma omega-3 levels are associated with improved exacerbation risk and respiratory-specific quality of life in COPD. Chronic Obstr. Pulmonary Dis. 11, 293–302 (2024).
Google Scholar
Jiménez-Cepeda, A. et al. Dietary intake of fatty acids and its relationship with FEV1/FVC in patients with chronic obstructive pulmonary disease. Clin. Nutr. ESPEN. 29, 92–96 (2019).
Google Scholar
Piao, Z. et al. The association between polyunsaturated fatty acids and chronic obstructive pulmonary disease: a meta-analysis. Food Funct. 15, 5929–5941 (2024).
Google Scholar
Wu, Y. et al. PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress. Antioxid. Redox Signal. 20, 1382–1395 (2014).
Google Scholar
Ma, H. et al. Sparstolonin B suppresses free fatty acid palmitate-induced chondrocyte inflammation and mitigates post-traumatic arthritis in obese mice. J. Cell. Mol. Med. 26, 725–735 (2022).
Google Scholar
Mao, Y. et al. STING-IRF3 triggers endothelial inflammation in response to free fatty acid-Induced mitochondrial damage in Diet-Induced obesity. Physiol. Behav. 176, 139–148 (2016).
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